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Shashikant R. Pattan ¹, Nachiket S. Dighe ¹, Anand A. Bukitagar ¹, Prerana A. Chavan ¹, Snehlata K. Tambe ¹, Deepak S. Musmade ¹, S. V. Hiremath ²

Affiliations
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., IN
2 Department of Pharmacology, JNMC, Belgaum, Karnataka, IN

Abstract

A new series of substituted phenylthiazole derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-convulsant activity by Maximal Electroshock Induced Convulsions in Rats, Pentylenetetrazole- Induced Convulsions in Rats, and Strychnine Induced Convulsions in Rats methods. Compounds C₁, C₂, C₃, C₄, C₅, D₁, D₂, D₃, D₄, D₅, E₁, E₂, E₃, and E₄ have been found to exhibit excellent anti-convulsant activity.

Keywords

Phenylthiazole, Anti-Convulsant.

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S. R. Pattan ¹, N. S. Dighe ¹, S. V. Hiremath ², A. N. Merekar ³, V. M. Gaware ¹, D. S. Musmade ¹, P. M. Gaikwad ⁴

Affiliations
1 Dept of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
2 Dept of Pharmacology, J.N Medical College, Belgaum, IN
3 Dept of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
4 Dept of Pharmacology, Pd. Dr. Vitthalrao Vikhe Patil College of Pharmacy, Ahmednagar, IN

Abstract

A new series if substituted 1, 4-Dihydropyridine derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-inflammatory activity by paw edema, xylene induced ear edema and cotton wool granuloma methods. Compounds C₄, C₅, C₆, C₇ and C₉ have been found to exhibit excellent anti-inflammatory activity.

Keywords

1, 4-Dihydropyridine, Anti-Inflammatory, CHN Analysis.

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